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M7152
Sigma
Magainin I
≥97% (HPLC)
| Amino Acid Sequence: | Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser |
| CAS Number: | 108433-99-4 |
| Linear Formula: | C112H177N29O28S |
| Molecular Weight: | 2409.85 |
| MDL number: | MFCD00133521 |
Description
| Application | Initial sites of magainin I binding to E. coli have been shown to be lipopolysaccharide. |
| Biochem/physiol Actions | Antibiotic peptide. Thought to preferentially bind to anionic phospholipids abundant in bacterial membranes with the formation of dynamic peptide-lipid supramolecular pore and cell permeabilization, magainins are positively charged and amphiphatic. Binding to artificial neutral membranes has also been demonstrated. |
Properties
| assay | ≥97% (HPLC) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Zasloff, M. Proc. Natl. Acad. Sci. U. S. A. 84, 5449, (1987) Abstract |
| Giovannini, M.G., et al. Biochem. J. 243, 113, (1987) Abstract | |
| Vorland, L.H., et al., Initial binding sites of antimicrobial peptides in Staphylococcus aureus and Escherichia coli. Scand. J. Infect. Dis. 31, 467-473, (1999) Abstract | |
| Huang, H., Action of antimicrobial peptides: Two-state model. Biochemistry 39, 8347, (2000) Abstract | |
| Wieprecht, T., Binding of antibacterial magainin peptides to electrically neutral membranes: thermodynamics and structure. Biochemistry 38, 10377, (1999) Abstract | |
| Helmerhorst, E.J., A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides. FEBS Lett. 449, 105, (1999) Abstract | |
| Matsuzaki K., Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim. Biophys. Acta 1376, 391-400, (1998) Abstract |
